中文Tshiab Coronavirus Variant Strain 501Y-V2 ntawm South Africa
Thaum Lub Kaum Ob Hlis 18th, 2020, South Africa tau kuaj pom 501Y-V2 mutant ntawm tus kabmob tshiab.Tam sim no South African mutant tau kis mus rau ntau tshaj 20 lub teb chaws.Cov kev sim tau pom tias saum toj no Tus Kab Mob Tshiab Corona-virus Mutants tuaj yeem nqa lwm yam kab mob Coronavirus tshiab ntawm K417N / T, E484K thiab N501Y kev hloov pauv uas tuaj yeem txo qis kev muaj peev xwm ntawm cov tshuaj tiv thaiv plasma neutralizing antibodies.Txawm li cas los xij, piv nrog cov ntaub ntawv siv genome Wuh01 (tus naj npawb MN908947), 501Y.V2 ntawm South African mutant genome ib ntus muaj 23 nucleotide variants.Nws muaj qhov hloov pauv N501Y tib yam li Britain mutant B.1.1.7 sub-type, tab sis tseem muaj kev hloov pauv ntawm ob qhov chaw tseem ceeb E484K thiab K417N ntawm S protein uas muaj feem cuam tshuam tseem ceeb ntawm kev muaj peev xwm kis tus kab mob.
Tus Kab Mob Coronavirus Tshiab yog ib tus kab mob RNA ib leeg, uas Genome kev hloov pauv ntau zaus.Kev kuaj pom ib leeg tuaj yeem yooj yim ua rau tsis pom cov qauv nrog cov kab mob qis thiab cov kab mob hloov pauv.Tus nqi ntawm kev rov ntsuam xyuas dua nyob rau hauv ib qho zoo hauv kev tshawb nrhiav lub hom phiaj, tuaj yeem ncav cuag ntau dua 10%, uas tuaj yeem ua rau muaj kev ua haujlwm ntau ntxiv thiab ncua sijhawm kuaj mob.Kev tshawb nrhiav ntau lub hom phiaj thiab kev sib koom ua pov thawj ntawm cov txiaj ntsig ntawm txhua lub hom phiaj tuaj yeem ua rau nce tus nqi nrhiav pom thiab pab txhawb kev kuaj mob ntxov.
Daim duab 1. Schematic daim duab ntawm tus kab mob tshiab Coronavirus mechanism
Tshiab Coronavirus Mutant B.1.1.7 ntawm Tebchaws Askiv
Thaum Lub Kaum Ob Hlis 26th, 2020, thawj daim ntawv tshawb fawb ntawm B.1.1.7 Strain tau luam tawm online.Lub koom haum ntawm Hygiene University of London UK thiab Cov Kab Mob Kub Kub, tau lees paub tias B.1.1.7 Strain muaj peev xwm kis tau ntau dua li lwm hom kab mob, uas yog ntau dua 56% (95% CI 50-74%).Vim tias qhov kev hloov pauv tshiab no muaj lub zog sib kis tau yooj yim dua, nws tau dhau los ua nyuaj dua los tswj COVID-19.Hnub tom qab, University of Birmingham hauv tebchaws United Kingdom tau tshaj tawm tsab xov xwm ntawm MedRxiv.Txoj kev tshawb nrhiav pom tias tus naj npawb ntawm ORF1ab thiab N tus kab mob gene luam hauv cov neeg mob uas kis tus kab mob B.1.1.7 mutant strain (S-gene dropout) tau nce ntxiv;qhov tshwm sim no tau saib xyuas hauv cov neeg.Cov kab lus no tau taw qhia tias cov neeg mob kis tus kabmob B.1.1.7 ntawm Tebchaws Askiv muaj cov kab mob ntau dua, yog li cov mutant no kuj tseem muaj cov kab mob ntau dua.
Daim duab 2. Lub genome mutation sequence muaj nyob rau hauv tus kab mob coronavirus mutant strain B.1.1.7 ntawm teb chaws Aas Kiv
Daim duab 3. N501Y kev hloov pauv tau tshwm sim hauv tebchaws Askiv thiab South AfricanVariants
Cov khoom siv kuaj pom tus mob Coronavirus tshiab
Chuangkun Biotech Inc. tau ua tiav cov khoom siv kuaj pom rau B.1.1.7 thiab 501Y-V2 cov kab mob coronavirus tshiab.
Qhov zoo ntawm cov khoom no: siab rhiab heev, ib txhij nrhiav tau ntawm 4 lub hom phiaj, npog lub ntsiab kev hloov chaw ntawm B.1.1.7 mutant strain thiab 501Y.V2 South African mutant strain.Cov khoom siv no tuaj yeem kuaj pom lub N501Y, HV69-70del, E484K qhov chaw hloov pauv thiab tus kab mob tshiab S gene ;Kev sim nrawm: nws tsuas yog siv sijhawm 1 teev 30 feeb los ntawm cov qauv sau kom tau txais txiaj ntsig.
Daim duab 4. Kev kuaj pom ntawm COVID-19 Britain Variant Amplification Curve
Daim duab 5. Kev kuaj pom ntawm COVID-19 South African Variant Amplification Curve
Daim duab 6. Wild-type of New coronavirus amplification curve
Nws tsis paub meej tias cov kev hloov pauv no ua rau muaj kev cuam tshuam ntev ntev ntawm kev sib kis thoob ntiaj teb COVID-19 txoj cai.Tab sis qhov no ua rau peb nco ntsoov tias cov kev hloov pauv no yuav cuam tshuam rau kev ua haujlwm ntawm kev tiv thaiv kab mob thiab kev tiv thaiv kab mob los ntawm kev txhaj tshuaj.Nws kuj tseem ceeb rau peb tias peb yuav tsum tau saib xyuas tus kabmob tshiab no mus ntev thiab hloov kho cov tshuaj tiv thaiv COVID-19 txhawm rau tiv thaiv kev hloov pauv ntawm tus kabmob tshiab.
Post lub sij hawm: Mar-12-2021